Carrick Therapeutics announces collaboration with Roche to evaluate novel Samuraciclib combination to treat HR+ breast cancer

Collaboration leverages Roche’s MORPHEUS platform to accelerate development of samuraciclib in combination with Roche’s giredestrant

Carrick Therapeutics, an oncology-focused biopharmaceutical company discovering and developing highly differentiated therapies, today announced a clinical collaboration with Roche to evaluate a novel combination of Carrick’s samuraciclib and Roche’s giredestrant in CDK4/6i resistant HR+, HER2- metastatic breast cancer. The collaboration will utilize Roche’s MORPHEUS Phase 1b/2 platform for rapid and efficient combination development, with upfront randomization versus a control group.

This new study expands Carrick’s portfolio of clinical trials with samuraciclib, which is also being evaluated in a Phase 2a study in combination with fulvestrant for CDK4/6i resistant HR+, HER2- metastatic breast cancer. Other ongoing studies include samuraciclib for the treatment of triple negative breast cancer (TNBC) and prostate cancer – all settings in which CDK7 has been shown to act as a regulator of transcription, the cell cycle and endocrine receptor signalling.

“We are excited to initiate this collaboration with Roche to explore the broad potential of samuraciclib in combination with giredestrant, a next-generation oral SERD. Carrick’s preclinical studies have shown strong synergy combining CDK7 inhibitors with endocrine therapies, including models of resistance to CDK4/6 inhibitors. This collaboration represents a shared commitment to maximize the potential of innovative combination treatment approaches and address significant unmet needs.” said Tim Pearson, Chief Executive Officer of Carrick Therapeutics

Under the agreement, each company is supplying its respective anti-cancer agent to support the trial.