Bicycle announces publication of article highlighting preclinical data from BT8009 program in molecular cancer therapeutics 

Bicycle Therapeutics plc (NASDAQ:BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) technology, today announced that an article highlighting preclinical data from BT8009, a Nectin-4 targeting Bicycle Toxin Conjugate, was published in Molecular Cancer Therapeutics. The article, titled “BT8009: a Nectin-4 targeting Bicycle® Toxin Conjugate for treatment of solid tumors” is available online via this link.

“Having already announced interim, positive results from our ongoing Phase I trial of BT8009, we are pleased to describe the work leading to its identification and the preclinical studies that support its potential to rapidly diffuse into, and to kill, solid tumor cells.” said Nicholas Keen, Ph.D., Chief Scientific Officer of Bicycle Therapeutics. “The data published in Molecular Cancer Therapeutics describe BT8009’s pre-clinical efficacy in a wide range of cell-derived xenograft and patient-derived xenograft tumor models, with full tumor regression frequently seen in large and small tumors. We look forward to providing additional clinical data on BT8009 later this year.