BT1718 is a potentially transformative treatment that has shown great promise in preclinical studies
The approximately 120-patient Phase I/IIa trial is designed to evaluate the safety and preliminary efficacy of BT1718 in patients with high expression of tumor MT1, as measured by a proprietary MT1 immunochemistry assay. Following a rapid dose escalation phase, the Phase I/IIa trial will evaluate two schedules of BT1718.
“We are excited to initiate this clinical study of BT1718, the first in a promising new class of potent anticancer agents with strong potential to deliver a meaningful therapeutic impact,” said Dr. Udai Banaji, Principal Investigator for the Phase I/IIa trial. “Our team is eager to evaluate this important new therapeutic in patients with advanced solid tumors.”
Dr. Nigel Blackburn, Cancer Research UK’s director of drug development, said: “BT1718 is a potentially transformative treatment that has shown great promise in preclinical studies, and trials like this are a big step towards helping more patients survive their cancer. We urgently need new, safe and effective therapies for patients with hard to treat cancers such as non-small cell lung cancer and triple negative breast cancer, which this drug will be tested on. Supporting this type of innovative clinical research is a key priority for Cancer Research UK.”
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