Bicycle Therapeutics is developing novel first-in-class medicines based on its Bicycle product platform. Bicycles can combine the properties of several therapeutic entities in a single modality: exhibiting the affinity and selective pharmacology associated with antibodies; the distribution kinetics of small molecules, allowing rapid tumour penetration; and the “tuneable” pharmacokinetic half-life and renal clearance of peptides.
Bicycle Therapeutics’ lead molecule, BT1718 is the first example of its Bicycle Drug Conjugate® (BDC) technology, in which toxic chemical payloads are targeted specifically to malignant tumours, minimising systemic toxin exposure through renal clearance. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MTP), which is highly expressed in many solid tumours, including triple negative breast cancer and non-small cell lung cancer. It is expected to enter the clinic in 2017 in partnership with Cancer Research UK. The Series B financing round will also fund additional pipeline programmes through early clinical development, the first of which will be selected in the second half of 2017.
Bicycle Therapeutics was co-founded by Professor Sir Gregory Winter, pioneer of therapeutic monoclonal antibodies and a member of CIC’s Advisory Panel. His work created a step change in the treatment of cancer and immune disorder and, as a result, many of the world’s blockbuster pharmaceutical drugs are based on the techniques he developed.
Dr Michael Anstey, Investment Director at CIC, says that Bicycles offer similar promise, "Bicycles are a new type of therapeutic that combine the best features of current approaches. They can penetrate tumours like small molecules, are specific like antibodies and are rapidly excreted like peptides, making them easy to administer and potentially avoiding the side-effects and limitations seen in the current treatments.
“The pre-clinical studies to date show Bicycles have an attractive profile. The next big step is to take this into humans and if they show the same characteristics this will be very exciting; offering a new choice of therapeutic.
"Bicycle Therapeutics is an ambitious company, with a world-class team, that has all the ingredients for another Cambridge success story."
“This financing represents an important validation of our approach, while providing Bicycle Therapeutics with the resources to continue to advance our pipeline and translate our bicyclic peptide technology into important new treatment options for patients,” said Dr Kevin Lee, Bicycle Therapeutics’ CEO. “We are grateful for the strong support from our investors as we move BT1718 rapidly towards the clinic and continue to advance our preclinical programmes, including toxin drug conjugates and immune modulators to treat cancer and other debilitating diseases.”