Bicycle Therapeutics has announced the appointment of Maria Koehler, M.D., Ph.D., as Chief Medical Officer. Dr. Koehler will lead clinical strategy and oversee operational functions for Bicycle’s clinical development team to bring BT1718 and additional Bicycles to patients for the treatment of a range of cancers with poor survival outcomes.

“We are delighted to welcome Maria to the Bicycle leadership team. As Chief Medical Officer, she will play a pivotal role in furthering our mission to transform the treatment regimens for cancer and other diseases,” said Dr. Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. “Maria has an exemplary track record, both as an oncology clinicianand researcher, and as a drug development expert. We look forward to drawing on her breadth of experience in the development, registration and launch of oncology drugs. This expertise will prove invaluable as we continue to advance our broad pipeline of oncology therapeutics including our lead program, BT1718, and further evolve Bicycle Therapeutics as an integrated pharmaceutical company.”

This is a tremendous opportunity to contribute to the clinical development of Bicycles, which are a truly innovative new class of cancer treatment

Maria Koehler, MD, PhD
Chief Medical Officer, Bicycle Therapeutics

Dr. Koehler, a trained oncologist with two decades of industry experience, joins Bicycle from Pfizer, where she was Vice President of Strategy, Innovation and Collaborations for the Oncology Business Unit. At Pfizer, Dr. Koehler was a key member of the oncology leadership team responsible for creating and coordinating innovative strategies for their oncology pipeline from early stage clinical trials through pivotal trials and product approval. Her accomplishments at Pfizer includeleading development strategies for Palbociclib/IBRANCE, which was launched in 2015, and shaping the oncology portfolio. Prior to joining Pfizer, Dr. Koehler was the Group Leader for the Medicine Development Center of GlaxoSmithKline Oncology, and a Senior Medical Director for Oncology Research and Development at AstraZeneca. During her academic career, she was the Clinical Director of Bone Marrow Transplantation at University Hospital in Pittsburgh, PA, and Director of the Bone Marrow Transplant Program and Associate Professor at St.Christopher’s Hospital in Philadelphia, PA. She is a Board Certified Hematology/Oncology physician, and the author of more than 160 peer reviewed publications and book chapters. Dr. Koehler received her M.D. and Ph.D. from the Silesian School of Medicine in Katowice, Poland.

“This is a tremendous opportunity to contribute to the clinical development of Bicycles, which are a truly innovative new class of cancer treatment with broad potential to make a life-changing impact on patients with cancer,” said Dr. Koehler. “I’m eager to work with the Bicycle team to bring these unique and powerful therapies to patients.”

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